Determinants of successful chronic hepatitis C case finding among patients receiving opioid maintenance treatment in a primary care setting.
نویسندگان
چکیده
AIMS Injection drug users are at high risk for chronic hepatitis C virus infection (CHC). Opioid maintenance treatment (OMT) offers a unique opportunity to screen for CHC. This study proposed the hypothesis that a general practitioner (GP) with special interest in addiction medicine can achieve CHC screening rates comparable to specialized centres and aimed to investigate determinants for a successful CHC case finding in a primary care setting. DESIGN AND PARTICIPANTS Retrospective medical record analysis of 387 patients who received opioid maintenance therapy between 1 January 2002 and 31 May 2008 in a general practice in Zurich, Switzerland. MEASUREMENTS Successful CHC assessment was defined as performance of hepatitis C virus (HCV) serology with consecutive polymerase chain reaction-based RNA and genotype recordings. The association between screening success and patient characteristics was assessed using multiple logistic regression. findings: Median (interquartile range) age and duration of OMT of the 387 (268 males) patients was 38.5 (33.6-44.5) years and 34 (11.3-68.0) months, respectively. Fourteen patients (3.6%) denied HCV testing and informed consent about screening was missing in 13 patients (3.4%). In 327 of 360 patients (90.8%) with informed consent a successful CHC assessment has been performed. Screening for HCV antibodies was positive in 136 cases (41.6%) and in 86 of them (63.2%) a CHC was present. The duration of OMT was an independent determinant of a successful CHC assessment. CONCLUSIONS In addicted patients a high CHC assessment rate in a primary care setting in Switzerland is feasible and opioid substitution provides an optimal framework.
منابع مشابه
Author's response to reviews Title: Patients receiving opioid maintenance treatment in primary care: Successful chronic hepatitis C care in a real world setting Authors:
متن کامل
Patients receiving opioid maintenance treatment in primary care: successful chronic hepatitis C care in a real world setting
BACKGROUND Injection drug users (IDUs) represent a significant proportion of patients with chronic hepatitis C (CHC). The low treatment uptake among these patients results in a low treatment effectiveness and a limited public health impact. We hypothesised that a general practitioner (GP) providing an opioid maintenance treatment (OMT) for addicted patients can achieve CHC treatment and sustain...
متن کاملHepatitis Infection in the Treatment of Opioid Dependence and Abuse
Many new and existing cases of viral hepatitis infections are related to injection drug use. Transmission of these infections can result directly from the use of injection equipment that is contaminated with blood containing the hepatitis B or C virus or through sexual contact with an infected individual. In the latter case, drug use can indirectly contribute to hepatitis transmission through t...
متن کاملارزیابی و مقایسه کیفیت زندگی بیماران مبتلا به هپاتیت B و C مزمن با افراد سالم در استان همدان
Introduction & Objective: Chronic hepatitis B and C will result in limitation of physical and mental functions which in turn reduce the quality of life (QOL) of the patients. The aim of this study was to determine the quality of life among chronic hepatitis B and/or C patients in Hamadan province from March 2011 to March 2012. Materials & Methods: A case- control study was done using SF-36 qu...
متن کاملSuccessful treatment of chronic hepatitis C virus infection in severely opioid-dependent patients under heroin maintenance.
BACKGROUND Severely opioid-dependent patients are at high risk of both acquiring and spreading the hepatitis C virus (HCV). It is uncertain, however, whether these patients are possible candidates for HCV treatment. We therefore explored treatment retention and adherence as well as sustained viral response in co-morbid severely opioid-dependent subjects under heroin maintenance, who previously ...
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عنوان ژورنال:
- Addiction
دوره 104 12 شماره
صفحات -
تاریخ انتشار 2009